STERILITY DIAGNOSIS

|STERILITY DIAGNOSIS
STERILITY DIAGNOSIS 2018-06-27T12:00:25+00:00

Project Description

Sterility Study

The infertility can be caused by masculine or feminine factors, or it can be mixed cause when it affects the two members of the couple.

When a couple consults for sterility, it is very important to evaluate each case to determine the complementary tests that we should request. We must analyze the medical history and lifestyle of the woman and her partner, because each case is different and the necessary diagnostic studies may be different.

Regarding the woman, through a gynecological ultrasound we will discard pathology. Also, we will make an antral follicle count to determine the oocyte reserve.

From there we will evaluate whether or not other studies are necessary:

  • Hormonal studies and Anti-Müllerian hormone (AMH): measure the reserve of ovules.
  • Hysterosalpingography (HSG): diagnoses obstructions in the fallopian tubes
  • Hysteroscopy (HSC): diagnoses and treats alterations in the uterus
  • Endometrial receptivity study
  • Karyotype, thrombophilia study, immunological studies…

Regarding the male factor, we must start from a reproductive seminogram to assess the diagnostic tests that should be requested.

Seminograma

El análisis del semen es fundamental para establecer posibles problemas de fertilidad masculina.

El seminograma reproductivo está enfocado a conocer cómo se comporta la muestra seminal en el laboratorio y a determinar la técnica reproductiva (IA, FIV y/o ICSI) adecuada a esa muestra.

En Reprofiv contamos con un privado masculino para recoger la muestra seminal, permitiendo su traslado inmediato al laboratorio para el análisis posterior.

  • Inicialmente se realiza una valoración macroscópica y se determina: volumen de eyaculado, pH, color, olor, viscosidad y tiempo de licuefacción; posteriormente se efectúa la valoración microscópica y se evalúa: la movilidad de los espermatozoides (siendo la movilidad  progresiva la determinante), la concentración (número de espermatozoides por ml de eyaculado) y la morfología (cabeza, cuello y cola de los espermatozoides). Con estos valores se determina el T.M.S. (número total en el eyaculado de espermatozoides con movilidad progresiva).

  • En segundo lugar se procede a realizar la  capacitación espermática que se puede hacer mediante dos procedimientos: swim-up (el que más utilizamos) y gradientes.

  • Tras ella se determina el R.E.M. (número de espermatozoides progresivos tras capacitación espermática). El R.E.M. (junto con la morfología) es un punto de corte para derivar la muestra seminal a una u otra técnica reproductiva.

  • Para establecer los valores de referencia nos basamos en los determinados  por la O.M.S. (2010).

  • En el mismo día, el biólogo informará adecuadamente al paciente o pareja  sobre el resultado del seminograma.

Genetic studies in spermatozoon

  • FISH IN ESPERMATOZOON
    There is an increase in aneuploidies (alterations in the number of chromosomes) in spermatozoon of infertile males compared with fertile males. The more severe the male factor is the higher number of aneuploidies. With the FISH procedure in sperm we know how many copies of a chromosome there are in each spermatozoa.

    In Reprofiv we perform the study of 5, 7 or 9 chromosomes in spermatozoon:

    • 5 chromosomes: sex chromosomes (X and Y), 13, 18 and 21
    • 7 chromosomes: sex chromosomes (X and Y), 13, 16, 18, 21 and 22
    • 9 chromosomes: sex chromosomes (X and Y), 13, 15, 16, 17, 18, 21 and 22
  • STUDY OF FRAGMENTATION OF SPERMATAL DNA: SINGLE CHAIN ​​AND DOUBLE CHAIN FRAGMENTATION.

    In recent years, the focus has been set on the role of the sperm in the reproductive process. Also, the technology to analyze the integrity of the sperm DNA has been improved and, more importantly, new techniques have been developed to treat those cases in which that DNA presents serious alterations that lead to sterility or to recurrent abortion.

    In collaboration with the company CIMAB, Reprofiv performs the novel and sensitive fragmentation of the of single chain and double chain analysis using the techniques of “Comet Alcalino and Comet Neutro”.

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Saturday 10:00 – 14:00

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